Two-Stage Dynamics ofIn VivoBacteriophage Genome Ejection
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چکیده
منابع مشابه
Dynamics of bacteriophage genome ejection in vitro and in vivo.
Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ∼500 mg ml(-1). This high density requires substantial compression of the normal B-form helix, leading to the conjecture that DNA in mature phage virions is under significant pressure, and that pressure is used to eject the DNA during infect...
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Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether it will be possible to detect interacting loci using realistic sample sizes in humans and to what extent undetected epistasis will adversely affect ...
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• Traditionally it has been taught that left ventricular pressure exceeds aortic pressure throughout the period of ventricular ejection. This concept is illustrated in the cardiac cycle diagram in Wigger's first edition of his textbook, Physiology in Health and Disease, and is repeated in most modern textbooks dealing with ventricular and arterial dynamics. Wiggers and Hamilton, working indepen...
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This paper was presented in part to the 50th Annuial Scientific Sessions, Americani Heart Association, Miami, Fla., Noveml)er 1977. The opinions or assertions expressed herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army of the Department of Defense. Received for publicatiotn 6 April 1979 anid inl revised formt 7 July 198...
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The much-anticipated fixed-array, genome-wide SNP genotyping technologies make large-scale genome-wide association scans now possible for large numbers of subjects. In this paper we reconsider the problem (Satagopan and Elston [2003] Genet Epidemiol 25:149-157) of optimizing a two-stage genotyping design to deal with important new issues that are relevant when studies are expanded from candidat...
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ژورنال
عنوان ژورنال: Physical Review X
سال: 2018
ISSN: 2160-3308
DOI: 10.1103/physrevx.8.021029